In 1961, an inventive Englishman, named Peter Mitchell, proposed a radically novel hypothesis to explain how energy is conserved during respiration and photosynthesis, and applied to the generation of ATP and other kinds of functional work. The chemiosmotic hypothesis sparked an intense controversy that lasted for 15 years. Today, Mitchell's conception of proton currents and their role in phosphorylation and active transport is generally accepted, and has ramified into many corners of cellular physiology. His most profound contribution may have been (...) to introduce spatial direction into biochemistry, and thereby transform our perception of the relationship between molecules and cells. BioEssays 23:848–855, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

In Marshall's Tendencies (Sutton, 2000), John Sutton poses some fairly deep questions for economists, especially for empirical work. In particular, when (if ever) is it safe to behave as though the applies? In that paradigm, we are attempting to extract and estimate the model from the data and are only kept from doing so because, while economic analysis captures the main , there are many small influences that we cannot exactly take into account. That paradigm, which Sutton traces to an (...) analogy of Marshall's likening economic predictions to predictions of the tides, leads to the econometric estimation of economic relationships, taking statistical account of the unincluded small influences by placing them in a random disturbance term. Sutton states (p. 5),. (shrink)

This work on index-number construction focuses on production indexes, including output and input deflators that can be used for constructing real output and real input. Fisher and Shell treat separately the different production units: the firm, the industry, and the economy, as well as the different forms of industrial organization: monopoly, monopsony, and competition. Only in the simplest cases is the appropriate theory isomorphic to that of the cost-of-living index because of the interlinkages among the various production units. A firm (...) cannot always assume that the behavior of its competitors, suppliers, and customers will be unaffected by price changes and only in special cases can an industry take supply and demand conditions as given. (shrink)

The views of some historians and philosophers of history as to the possibility of fruitful historical generalization seem at odds with the underlying methodology of the other social sciences. A formal model of the world historical process is here presented within which this apparent contradiction is seen to be resolvable in terms of modern theories of probability and stochastic processes. This is done by giving rigorous form to procedures and statements in the social sciences. A formal treatment of the dependence (...) of an investigation in one discipline on previous studies both in that area and in other social and natural sciences then follows naturally. (shrink)

First Considerations, says Weiss, “is perhaps my best and last attempt” to describe reality and knowledge. As a consequence of the desire to clarify his own philosophical position, Weiss invited a number of philosophers whom he did not expect to agree with his philosophy to examine it carefully and to present to him their criticisms. Six philosophers responded to the invitation, and their comments, with Weiss’s replies, constitute the second part of the book. In these comments almost all of Weiss’s (...) basic ideas are challenged. Both the criticisms and the replies serve to clarify Weiss’s philosophy. (shrink)

First Considerations, says Weiss, “is perhaps my best and last attempt” to describe reality and knowledge. As a consequence of the desire to clarify his own philosophical position, Weiss invited a number of philosophers whom he did not expect to agree with his philosophy to examine it carefully and to present to him their criticisms. Six philosophers responded to the invitation, and their comments, with Weiss’s replies, constitute the second part of the book. In these comments almost all of Weiss’s (...) basic ideas are challenged. Both the criticisms and the replies serve to clarify Weiss’s philosophy. (shrink)

According to Thompson, since Tillich believes that the modern scientific and philosophic views of reality do not provide an adequate ontological foundation for human values, he attempts to convert the present generation to a new philosophy which overcomes this deficiency. The principal "task" of Being and Meaning, says Thompson, is to examine Tillich's new philosophy to determine whether it fulfills the criteria of adequacy, comprehensiveness, coherence, and consistency. Thompson insists that since Tillich feels an urgent need to convert his contemporaries (...) to his philosophy of life, he adopts the style of the rhetorician and thus attempts to persuade others rather than to convince them by logical proof of the truth of particular ideas within his system. "Tillich's Systematic Theology has the character of a belief-system rather than a system of theoretical knowledge". Nevertheless, Thompson indicates that Tillich's philosophy as a whole has an impressive consistency and coherence. However, he contends that Tillich fails to justify particular ideas in his philosophy. (shrink)

According to Oppenheim, "The present study aims to bring the American philosopher Josiah Royce out of the shadows that often cover his final decade". More precisely, he contends, it aims to discern and to relate accurately Royce's doctrine and method in his mature philosophy of religion. Even more specifically, says Oppenheim, the study "aims carefully to search out from Royce's The Problem of Christianity his principal and subordinate methods and accurately to identify his human and 'Christian' doctrines as rooted in (...) experience". Oppenheim insists "that the mature Royce identified and carried out, in a generally successful way, both a new and fully human method of philosophizing and a Christian metaphysics of community". Royce's greatest achievement may be his employment of a new method in philosophy of religion. (shrink)

The potential health risks of vegan diets specifically for women and children are discussed. Women and children are at higher risk of malnutrition from consumption of unsupplemented vegan diets than are adult males. Those who are very young, pregnant, lactating, elderly, or who suffer from poverty, disease or other environmentally induced disadvantages are at special risk. The size of these risks is difficult to quantify from existing studies. Fortunately the risk of dietary deficiency disease can be avoided and the potential (...) health benefits of vegan diets can be realized when diets for these groups are planned in line with theRecommended Dietary Allowances so that nutrient intakes reach or exceed recommended levels, and access to preventive and curative health services is assured. (shrink)

This article examines whether the degree of religiosity in an institutional environment can stimulate the emergence of a robust corporate governance system. This study utilizes the Nigerian business environment as its context and embraces a qualitative interpretivist research approach. This approach permitted the engagement of a qualitative content analysis (QCA) methodology to generate insights from interviewees. Findings from the study indicate that despite the high religiosity among Nigerians, religion has not stimulated the desired corporate governance system in Nigeria. The primary (...) explanation for this outcome is the presence of rational ordering over religious preferences thus highlighting the fact that religion, as presently understood and practiced by stakeholders, is inconsistent with the principles underpinning good corporate governance. (shrink)

The use of brain imaging technology as a common tool of research has spawned concern and debate over how investigators should respond to incidental fndings discovered in the course of research. In this article, we argue that investigators have an obligation to respond to incidental fndings in view of their entering into a professional relationship with research participants in which they are granted privileged access to private information with potential relevance to participants' health. We discuss the scope and limits of (...) this professional obligation to respond to incidental fndings, bearing in mind that the relationship between investigators and research participants differs fundamentally from the doctor-patient relationship. (shrink)

The Search for the Legacy of the USPHS Syphilis Study at Tuskegee is a collection of essays from experts in a variety of fields seeking to redefine the legacy of the infamous Tuskegee Syphilis Study. The essayists place the legacy of the study within the evolution of racial and ethnic relations in the United States. Contributors include two leading historians on the study, two former United States Surgeons General, and other prominent scholars from a wide range of fields.

From Abraham to Abu Ghraib, from the dissenting prophets to Darfur, he probes history, the Bible and the works of contemporary thinkers for ideas about both ...

Conscious events interact with memory systems in learning, rehearsal and retrieval (Ebbinghaus 1885/1964; Tulving 1985). Here we present hypotheses that arise from the IDA computional model (Franklin,Kelemen and McCauley 1998; Franklin 2001b) of global workspace theory (Baars 1988, 2002). Our primary tool for this exploration is a flexible cognitive cycle employed by the IDA computational model and hypothesized to be a basic element of human cognitive processing. Since cognitive cycles are hypothesized to occur five to tentimes a second (...) and include interaction between conscious contents and several of the memory systems, they provide the means for an exceptionally fine-grained analysis of various cognitive tasks. We apply this tool to the small effect size of subliminal learning compared to supraliminal learning, to process dissociation, to implicit learning, to recognition vs. recall, and to the availability heuristic in recall. The IDA model elucidates the role of consciousness in the updating of perceptual memory, transient episodic memory, and procedural memory. In most cases, memory is hypothesized to interact with conscious events for its normal functioning. The methodology of the paper is unusual in that the hypotheses and explanations presented are derived from an empirically based, but broad and qualitative computational model of human cognition. (shrink)

The low rates of regular exercise and overall physical activity (PA) in the general population represent a significant public health challenge. Previous research suggests that, for many people, exercise leads to a negative affective response and, in turn, reduced likelihood of future exercise. The purpose of this paper is to examine this exercise–affect–adherence relationship from an evolutionary perspective. Specifically, we argue that low rates of physical exercise in the general population are a function of the evolved human tendency to avoid (...) unnecessary physical exertion. This innate tendency evolved because it allowed our evolutionary ancestors to conserve energy for physical activities that had immediate adaptive utility such as pursuing prey, escaping predators, and engaging in social and reproductive behaviors. The commonly observed negative affective response to exercise is an evolved proximate psychological mechanism through which humans avoid unnecessary energy expenditure. The fact that the human tendencies toward negative affective response to and avoidance of unnecessary physical activities are innate does not mean that they are unchangeable. Indeed, it is only because of human-engineered changes in our environmental conditions (i.e., it is no longer necessary for us to work for our food) that our predisposition to avoid unnecessary physical exertion has become a liability. Thus, it is well within our capabilities to reengineer our environments to once again make PA necessary or, at least, to serve an immediate functional purpose. We propose a two-pronged approach to PA promotion based on this evolutionary functional perspective: first, to promote exercise and other physical activities that are perceived to have an immediate purpose, and second, to instill greater perceived purpose for a wider range of physical activities. We posit that these strategies are more likely to result in more positive (or less negative) affective responses to exercise, better adherence to exercise programs, and higher rates of overall PA. (shrink)